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Diamox: When Should You Start Taking This Medication?

April 6, 2026

Quick Answer

You should start taking Diamox, also known as acetazolamide, 24 hours before ascending to high altitudes or as soon as possible if you're already experiencing symptoms of altitude sickness. This allows the medication to take effect and help prevent the onset of more severe symptoms.

Pre-Ascending Medication Protocol

When ascending to high altitudes, it’s essential to take Diamox 24 hours prior to reaching elevations above 8,000 feet (2,438 meters). Start by taking a 250mg tablet twice a day, 24 hours before ascending. This allows the medication to start working, helping to prevent the onset of altitude sickness.

Early Signs of Altitude Sickness

If you’re already experiencing symptoms of altitude sickness, such as headaches, nausea, or fatigue, take Diamox as soon as possible. Start with a dose of 250mg twice a day and adjust as needed based on your response to the medication. Monitor your symptoms closely and be prepared to descend if they worsen.

Descending and Continuing Treatment

If you’re experiencing severe symptoms of altitude sickness, immediately descend to a lower elevation. Continue taking Diamox at the same dose until your symptoms resolve, usually within 24-48 hours after descent. Once your symptoms have subsided, you may gradually increase your altitude exposure, but it’s crucial to continue monitoring your body’s response to the higher elevation.

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