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How to perform a self-administered EpiPen injection?

April 5, 2026

Quick Answer

To administer an EpiPen, hold the device at a 90-degree angle to your thigh and squeeze it firmly for 3 seconds. This will release the epinephrine into your body. If the device does not automatically eject the needle, do not force it.

Preparing for an EpiPen Injection

Before using an EpiPen, make sure you have a clean and dry surface to perform the injection. Remove the device from the protective case and place it on the surface. Remove the safety cap by pulling it straight down. Visually inspect the device to ensure it is ready for use.

Administering the Injection

Identify the correct injection site, which is the middle of your outer thigh, 2.5 cm away from the crease where your leg bends. Hold the EpiPen at a 90-degree angle to your thigh with the tip pointed towards your hip. Place your thumb on top of the device and your index finger on the bottom. Use your thumb to stabilize the device and your index finger to squeeze it firmly for 3 seconds. You will hear a clicking sound when the device ejects the needle and releases the epinephrine. Hold the device in place for 3 additional seconds to ensure the needle is fully inserted.

Managing Post-Injection

After administering the EpiPen, call 911 or your local emergency number immediately. Even if your symptoms improve, you may still need medical attention. The epinephrine from the EpiPen will start to wear off within 20 minutes. If you are experiencing continued symptoms, another dose of epinephrine may be necessary. Always carry a spare EpiPen with you in case of a second emergency.

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